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Cvb2abmsmtcsf

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies against Coxsackievirus B2 in the cerebrospinal fluid to help diagnose viral infections affecting the brain or nervous system.

Quick summary

{"The test looks for immune response to Coxsackievirus B2 in spinal fluid","It helps doctors diagnose viral infections of the brain, meninges, or nervous system","A positive result suggests a recent or past infection with this specific virus","The sample is collected through a lumbar puncture (spinal tap)","Results are used alongside clinical symptoms and other tests for diagnosis"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109907-6
Short code
CVB2 Ab CSF
Synonyms
CV B2 Ab Msmt CSF
Category
cardiac
Sample
csf
Container
Sterile polypropylene tube for CSF collection
Units
N/A
Ref low
0
Ref high
1
Fasting
false
Population
adult
Sex
all
Age range
≥ 0 years
Method
Enzyme-linked immunosorbent assay (ELISA) or Immunofluorescence assay (IFA)
CPT
86658
SNOMED
371949004
Specimen volume
1-2 mL of cerebrospinal fluid
Stability
Store at 2-8°C if testing within 24-48 hours; for longer storage, freeze at -20°C or below. Avoid repeated freeze-thaw cycles.
Hemolysis max
200
TAT
48–168 hours
Order
routine

What is this test?

The Coxsackievirus B2 antibody test is a laboratory test that detects whether your immune system has produced specific antibodies against Coxsackievirus B2, a type of enterovirus. The test is performed on cerebrospinal fluid (CSF), which is the clear fluid that surrounds your brain and spinal cord. This fluid is collected through a procedure called a lumbar puncture, also known as a spinal tap.

Why is it ordered?

This test is ordered when a patient shows symptoms of a viral infection affecting the central nervous system, such as meningitis (inflammation of the membranes covering the brain), encephalitis (inflammation of the brain), or other neurological symptoms. Coxsackievirus B2 can sometimes cause these types of infections, and identifying the specific cause helps guide appropriate treatment.

What happens during the test?

A healthcare provider will collect cerebrospinal fluid by inserting a thin needle into the lower part of your spine. You will typically lie on your side with your knees drawn up to your chest. The area will be cleaned and numbed with a local anesthetic. The procedure takes about 15-30 minutes, and you may be asked to remain lying flat for a short time afterward to reduce the risk of headache.

Understanding your results

A positive result means that antibodies to Coxsackievirus B2 were detected in your cerebrospinal fluid, suggesting that your body has mounted an immune response to this particular virus. A negative result means no antibodies were detected. Your doctor will interpret these results in combination with your symptoms, physical examination, and other laboratory tests to make a diagnosis.

Reference range

Negative or <1:4 titer; detection of Coxsackievirus B2 IgM or IgG antibodies in CSF may indicate recent or past infectionN/A

Specimen: csf

No specific preparation required. Inform patient about lumbar puncture procedure and obtain informed consent. No fasting required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings2

Frequently asked questions

Is this test painful?
The lumbar puncture itself may cause some discomfort or pressure, but the area is numbed with a local anesthetic to minimize pain. You may feel a brief sting during the injection. Some people experience a headache afterward, which can usually be managed with rest and fluids.
How long does it take to get results?
Results may take several days to a week, as the sample often needs to be sent to a specialized laboratory. The test requires specific techniques to detect antibodies in the cerebrospinal fluid.
Do I need to prepare for the test?
Your healthcare provider will give you specific instructions. Generally, you should inform them about any medications you are taking, especially blood thinners. You may need to stop certain medications before the procedure. Follow your provider's guidance about eating and drinking before the test.
What are the risks of a lumbar puncture?
The most common risk is a headache that can last for a few days. Less common risks include bleeding, infection, or back pain at the puncture site. Serious complications are rare. Contact your healthcare provider if you experience severe headache, fever, or unusual symptoms after the procedure.
  1. 1
    Coxsackievirus Infections - MedlinePlusSource
  2. 2
    Lumbar Puncture (Spinal Tap) - Johns Hopkins MedicineSource
  3. 3
    Enterovirus Infections - CDCSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy