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Cvb3abmsmtcsf

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies against Coxsackievirus B3 in cerebrospinal fluid to help diagnose viral infections of the brain and nervous system.

Quick summary

{"Detects immune response to Coxsackievirus B3 in the brain and spinal cord","Helps diagnose viral meningitis, encephalitis, or meningoencephalitis","Sample is collected via lumbar puncture (spinal tap)","Results indicate past or current infection","Often used alongside other tests for complete diagnosis"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109906-8
Short code
COX B3 Ab CSF
Synonyms
CV B3 Ab Msmt CSF
Category
cardiac
Sample
csf
Container
Sterile screw-cap container for CSF collection (avoid collection in tubes containing preservatives or anticoagulants)
Units
N/A
Ref low
1
Ref high
1.5
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
Enzyme immunoassay (EIA) or immunofluorescence assay (IFA)
CPT
86658
SNOMED
122442009
Specimen volume
1-2 mL of cerebrospinal fluid
Stability
Refrigerated (2-8°C) for up to 72 hours; frozen (-20°C or below) for longer storage up to several weeks. Avoid repeated freeze-thaw cycles.
Hemolysis max
200
TAT
48–168 hours
Order
routine

What is this test?

The Coxsackievirus B3 antibody test detects specific antibodies (IgM and IgG) that your immune system produces in response to Coxsackievirus B3 infection. This test is performed on cerebrospinal fluid (CSF), the clear fluid that surrounds your brain and spinal cord. The presence of these antibodies in CSF indicates that the virus has infected the central nervous system.

Why is this test ordered?

Your doctor may order this test if you have symptoms of a central nervous system infection such as fever, severe headache, stiff neck, confusion, seizures, or altered consciousness. Coxsackievirus B3 is a common cause of viral meningitis and encephalitis, especially in summer and fall. This test helps distinguish viral infections from bacterial infections, which is critical for determining appropriate treatment.

How is the sample collected?

The sample is collected through a procedure called lumbar puncture or spinal tap. A healthcare provider inserts a thin needle between two vertebrae in your lower back to collect cerebrospinal fluid. The procedure usually takes about 15-30 minutes. You may experience some discomfort or headache afterward, which typically resolves with rest and hydration.

What do the results mean?

A positive result means antibodies against Coxsackievirus B3 were detected in your CSF, indicating a recent or current infection of the central nervous system. A negative result suggests no current infection, though it does not rule out infection entirely—antibodies may not yet have developed in very early infection. Your doctor will interpret these results together with your symptoms, physical exam, and other test results.

Reference range

Negative: <1:8 titer or <1.0 index; Equivocal: 1:8 to 1:32 titer or 1.0-1.5 index; Positive: >1:32 titer or >1.5 indexN/A

Specimen: csf

No special preparation required. Patient should be informed about the lumbar puncture procedure and potential risks. Obtain informed consent before CSF collection.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Is this test painful?
The lumbar puncture may cause brief discomfort or a stinging sensation. Local anesthetic is usually used to minimize pain. You may feel pressure as the needle is inserted. Most patients experience only mild discomfort during and after the procedure.
How long does it take to get results?
Results are typically available within 3-7 days, as the test requires specialized laboratory analysis to detect antibodies in cerebrospinal fluid.
Do I need to fast before this test?
No fasting is required for this test. However, you should inform your doctor about any medications you are taking, as some drugs may affect test results.
What is the difference between IgM and IgG antibodies?
IgM antibodies are produced first and indicate recent or active infection. IgG antibodies develop later and provide long-term immunity. Detecting IgM in CSF suggests current infection, while IgG may indicate past exposure.
Is Coxsackievirus B3 the same as hand, foot, and mouth disease?
No, Coxsackievirus B3 is different from the viruses that cause hand, foot, and mouth disease (usually Coxsackievirus A16 or Enterovirus 71). Coxsackievirus B3 is more commonly associated with meningitis, encephalitis, and myocarditis.
  1. 1
    Coxsackievirus B Infections - Clinical OverviewSource
  2. 2
    Viral Meningitis - Patient InformationSource
  3. 3
    Lumbar Puncture (Spinal Tap) - Procedure InformationSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy