C-reactive protein (CRP) measurement by high-performance liquid chromatography (HPLC) or similar quantitative method

Why Is This Test Done? Your doctor may order this test to check how well your body is working, look for early signs of illness, or monitor a condition you already have. The results give your care team important information that helps guide diagnosis, treatment decisions, and your follow-up care plan.

Your healthcare provider may order this test to check for signs of inflammation, monitor chronic conditions, or evaluate symptoms like fever, joint pain, or swelling. It can also help assess risks for heart disease or other inflammatory disorders.

What to Expect Before the Test: Your care team will give you clear instructions on how to prepare. You may be asked to avoid food or drinks for a set period of time, pause certain medicines or supplements, or wear loose, comfortable clothing. Be sure to mention any allergies, medicines you take, or health conditions so the test can be done safely.

No special preparation is needed. You may have a blood sample drawn from a vein in your arm, typically during a routine office visit or lab visit. If you’re taking certain medications, let your provider know.

What Are Possible Results? Results are usually reported as normal or abnormal. A normal result means your values fall within the expected range for a healthy person. An abnormal result does not automatically mean something is seriously wrong; it simply gives your provider more information to decide whether you need further testing, closer monitoring, or treatment.

Results are interpreted by your healthcare provider based on your health history and symptoms. Elevated levels may indicate inflammation, while normal levels suggest no active inflammation.

Common Conditions Monitored: This type of testing is often used to keep track of ongoing conditions such as diabetes, high blood pressure, high cholesterol, thyroid problems, kidney disease, and anemia. Regular monitoring shows how well your treatment is working and helps your provider adjust your care plan when needed.

CRP is often used to monitor conditions like rheumatoid arthritis, lupus, infections, or after surgery to check healing progress. It may also be part of a general health screening.