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CXCL13 (Serum/plasma Substance Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of CXCL13, a protein involved in immune response and B-cell activation, found in your blood.

Quick summary

["CXCL13 helps identify immune system activity and potential conditions affecting B-cells."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49477-3
Short code
CXCL13 Ag Tiss Ql ImStn
Synonyms
CXCL13 Ag Tiss Ql ImStn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
immune-stain
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is CXCL13 Used For?

CXCL13 is primarily studied in research for conditions like autoimmune diseases, certain cancers, and chronic inflammatory disorders. It may also be explored in diagnosing or monitoring immune-related conditions where B-cell activity is suspected.

How Is the Sample Collected?

A blood sample is drawn from a vein, usually in your arm. This sample is then processed into serum or plasma for testing.

How Does This Test Work?

The test detects CXCL13 levels using an immunoassay method, which identifies the protein in your blood by binding to specific antibodies.

When Might You Need This Test?

Your healthcare provider may order this test if you have symptoms or conditions linked to immune system dysfunction, chronic inflammation, or suspected B-cell disorders. It may also be part of research studies or specialized diagnostic protocols.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: CXCL13 plays a role in immune cell signaling, particularly in B-cell development and activation. Elevated levels may suggest autoimmune diseases, certain infections, or conditions affecting the immune system. Further clinical correlation with symptoms and other tests is essential for accurate diagnosis.

Short name

CXCL13 Level

Frequently asked questions

Why might my doctor order this test?
Your doctor may recommend this test if you have symptoms like chronic fatigue, unexplained infections, or autoimmune symptoms, or if you’re part of a research study investigating immune-related conditions.
What are the possible results and what do they mean?
Results are qualitative (present/absent) or quantitative (measured concentration), but exact reference ranges are not universally established. Interpretation depends on clinical context, including your symptoms and other test results.
Is there any preparation needed before the test?
No special preparation is required. However, inform your healthcare provider about any medications or conditions that might affect results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy