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CXCR4 Gene Mutation Detection by Next-Generation Sequencing (NGS)

Published: August 9, 2026Updated: August 16, 2026

This test checks for specific changes (mutations) in the CXCR4 gene, which may influence how your body responds to certain conditions like infections or cancer.

Quick summary

["This test helps assess genetic variations linked to immune function and disease risk."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
104321-5
Short code
CXCR4 gene Mut Anl Bld/T
Synonyms
CXCR4 gene Mut Anl Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have a family history of certain genetic disorders, are being evaluated for conditions like leukemia, lymphoma, or HIV-related complications, or if you’re considering stem cell transplantation. It can also be used in research or clinical trials.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, which is typically collected by a healthcare professional in a clinic or lab. The sample is processed to analyze genetic material.

What the Test Measures

The test detects mutations in the CXCR4 gene, which encodes a protein involved in cell signaling. Mutations may affect how cells migrate, respond to signals, or interact with other cells, potentially influencing health outcomes.

How Results Are Interpreted

Results are compared to known genetic databases. A positive result indicates the presence of a mutation; a negative result means no detectable mutation was found in this sample. Interpretation depends on clinical context and family history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

CXCR4 mutations can play a role in diseases like certain cancers (e.g., T-cell leukemia), HIV progression, or immune-related disorders. They may also influence responses to treatments like stem cell transplants or targeted therapies. Genetic counseling may be recommended to discuss implications for you or future generations.

Short name

CXCR4 Gene Mutation Test

Frequently asked questions

What does a positive result mean?
A positive result means the test identified a mutation in your CXCR4 gene. This may suggest an increased risk for certain conditions or influence how you might respond to treatments, but results are always reviewed in the context of your medical history and symptoms.
Will this test affect my insurance or treatment options?
This test is typically covered by insurance if medically necessary, but coverage depends on your plan and clinical indication. Always confirm with your insurance provider. Treatment options may be tailored based on genetic findings, but decisions are made collaboratively with your healthcare team.
How long will it take to get my results?
Results are usually available within 2–4 weeks, depending on lab processing times and complexity. Your healthcare provider will contact you directly with the results and next steps.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy