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Cyclosporine Blood Concentration (Pharmacokinetic Monitoring)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of cyclosporine, a medication used to prevent organ rejection after a transplant or to control autoimmune conditions like rheumatoid arthritis or psoriasis, in your blood. It helps doctors determine if your dose is working effectively.

Quick summary

["Your cyclosporine dose is tailored to this specific blood level for safety and effectiveness."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
108279-1
Short code
cycloSPORINE Bld LC/MS/MS-sCnc
Synonyms
cycloSPORINE Bld LC/MS/MS-sCnc
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
0
Ref high
100
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
lc-ms-ms
CPT
83721
SNOMED
113079007
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Matters

Cyclosporine works by suppressing your immune system, but too much can cause serious side effects. Regular monitoring ensures your dose stays within safe and therapeutic ranges to prevent rejection or complications.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm or vein for a blood draw, similar to other routine blood tests. The process takes about 5 minutes.

What the Results Mean

Results help your healthcare provider adjust your medication if needed. They’ll discuss any changes with you during your follow-up visit.

Common Reasons for Testing

Doctors order this test to monitor cyclosporine levels in patients on long-term therapy, especially after organ transplants or for autoimmune diseases, to balance immune suppression and avoid side effects.

Reference range

Optimal: <100 mg/dLN/A

Specimen: whole-blood

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Cyclosporine Level

Frequently asked questions

How often should I get this test?
Your doctor will determine the frequency based on your treatment plan, but it’s often done weekly or monthly during active therapy to ensure your levels stay within the target range.
What happens if my cyclosporine level is too high?
High levels can increase the risk of kidney damage, infections, or other serious side effects. Your doctor may reduce your dose or switch medications if needed.
Can I eat or drink before this test?
You can eat and drink normally before the test, as it’s a simple blood draw with no fasting required.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy