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Cyclosporine Drug Level (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the concentration of cyclosporine, a medication used to suppress the immune system, often prescribed for organ transplants or autoimmune conditions. It helps ensure your dose is properly managed to avoid side effects or rejection.

Quick summary

["Your cyclosporine level helps doctors balance safety and effectiveness of your medication."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73426-9
Short code
cycloSPORINE ind plt IgM SerPl Ql FC
Synonyms
cycloSPORINE ind plt IgM SerPl Ql FC
Category
hematology
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Cyclosporine is a powerful drug that works by lowering your immune system’s activity. Keeping your levels within a target range is critical to prevent complications like organ rejection or excessive immune suppression. Your doctor may order this test to monitor your response to treatment, especially if you’re on a transplant program or have a condition requiring long-term immunosuppression.

What to Expect Before the Test

No special preparation is needed for this test. You’ll have a small needle inserted into your arm or vein to draw a blood sample. It usually takes a few minutes. If you’re taking cyclosporine orally, it’s best to have your blood drawn at a similar time each day to track levels accurately.

How the Results Are Used

Your results will be compared to a target range set by your healthcare provider. If levels are too high, it may increase your risk of side effects like kidney problems or infections. If levels are too low, your body might reject a transplanted organ or your condition could worsen. Your doctor will adjust your dose based on these findings.

Common Side Effects to Watch For

Cyclosporine can cause side effects like high blood pressure, kidney issues, or increased risk of infections. If you experience nausea, tremors, or unusual fatigue, let your doctor know—these could signal your levels are off target.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Regular cyclosporine level monitoring is essential for patients on long-term immunosuppression. It helps prevent complications like organ rejection, infections, or chronic kidney damage. Doctors use these results to optimize dosing and ensure the medication remains effective while minimizing risks. Levels may vary based on factors like diet, other medications, or how your body processes the drug.

Short name

Cyclosporine Level

Frequently asked questions

How often will I need this test?
The frequency depends on your treatment plan. For transplant patients, tests may be done weekly or monthly at first, then less often as your levels stabilize. Your doctor will schedule it based on your individual needs and how your body responds to the medication.
What if my test results are outside the normal range?
If your cyclosporine level is too high, your doctor may reduce your dose or switch to a different medication. If it’s too low, they might temporarily increase your dose or adjust other medications that could affect cyclosporine levels. Always follow their instructions carefully.
Can diet or other medications affect this test?
Yes, certain foods (like grapefruit) and other drugs (like antibiotics or antifungals) can change how cyclosporine works in your body. Always tell your doctor about all medications, supplements, or foods you’re taking to avoid interactions that could alter your test results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy