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Cyclosporine concentration (serum/plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of cyclosporine, a medication used to prevent organ rejection after a transplant or to reduce immune system activity in certain conditions, in your blood.

Quick summary

["Your cyclosporine level helps doctors monitor whether your dose is safe and effective."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
34426-7
Short code
cycloSPORINE monocl SerPl-mCnc
Synonyms
cycloSPORINE monocl SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Cyclosporine is a powerful medication that works by suppressing your immune system. Keeping your levels within a target range is crucial to avoid side effects like infections or organ damage while ensuring the medication works properly. Your doctor may order this test to check if your dose is correct, especially if you’re taking it for long-term use or after a transplant.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for a few hours before the test if it’s drawn in the morning. Bring a list of all medications you’re taking, including supplements, as some can affect your results. If you’re pregnant, breastfeeding, or have allergies, let your healthcare provider know.

What the Test Involves

A healthcare professional will draw blood from a vein in your arm. The blood sample will be sent to a lab for analysis using a technique called immunoassay, which detects the presence of cyclosporine in your serum or plasma.

What the Results Mean

Results are typically reported as a mass concentration (in micrograms per milliliter or nanograms per milliliter). Your doctor will compare these results to your target range, which may vary based on your condition, age, and other factors. If your levels are too high or too low, your doctor may adjust your medication dose.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Cyclosporin Level

Frequently asked questions

Why might my doctor order this test?
Your doctor may order this test to monitor your cyclosporine levels if you’re taking this medication to prevent organ rejection after a transplant, treat autoimmune diseases like rheumatoid arthritis or lupus, or manage certain skin conditions. Regular testing helps ensure your dose is effective and safe, reducing the risk of side effects like kidney damage, high blood pressure, or infections.
How often should I get this test?
The frequency depends on your treatment plan. For example, after a transplant, you might need testing every few weeks at first, then less often as your body adjusts. If you’re taking cyclosporine for a long-term condition, your doctor may check your levels every few months or as needed. Always follow your healthcare provider’s instructions.
What happens if my cyclosporine level is too high or too low?
If your levels are too high, you may experience side effects like nausea, tremors, high blood pressure, or kidney problems. If they’re too low, your medication may not work as intended, increasing your risk of organ rejection (after transplant) or flare-ups of your condition. Your doctor will work with you to adjust your dose based on your results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy