Skip to content

CYP1A2 Genotype (C*1*5090 Variant) via Carrier Screening or Prenatal Testing

Published: August 9, 2026Updated: August 16, 2026

This test checks for a specific genetic variation in the CYP1A2 gene, which influences how your body processes certain medications and chemicals. It may be used in carrier screening, prenatal testing, or assessing drug metabolism.

Quick summary

["Genetic variation in CYP1A2 can affect how your body breaks down medications and toxins."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
75720-3
Short code
CYP1A2 c.5090C>T Bld/T Ql
Synonyms
CYP1A2 c.5090C>T Bld/T Ql
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

The CYP1A2 gene encodes an enzyme that helps metabolize drugs like caffeine, certain antidepressants, and some antibiotics. The variant in question (C*1*5090) is a rare genetic change that may alter enzyme function. This test identifies whether you carry this variant, which could influence how your body processes medications or environmental compounds.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you are at risk for genetic conditions affecting drug metabolism, such as in prenatal screening, carrier testing for families with a history of metabolic disorders, or if you’re considering medications known to interact with CYP1A2.

Common Uses and Considerations

This test is often used in specialized settings like genetic counseling, prenatal care, or for individuals taking medications that require precise dosing based on metabolism. It’s not a routine blood test but may be part of a broader genetic evaluation.

What to Expect Before the Test

No special preparation is needed unless specified by your provider. The test typically involves a simple blood draw or, in some cases, a saliva sample for genetic testing. Results are analyzed by a genetic counselor or laboratory specialist.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Variants in the CYP1A2 gene can affect how efficiently your body breaks down medications like caffeine, some antidepressants, or anti-inflammatory drugs. Rarely, it may influence sensitivity to environmental toxins. If you carry this variant, your provider may recommend alternative medications or monitor you more closely for side effects.

Short name

CYP1A2 Gene Variant Test

Frequently asked questions

What does a positive result mean?
A positive result means you carry the C*1*5090 variant in your CYP1A2 gene. This may indicate altered drug metabolism, though symptoms or effects depend on other genetic factors and the specific medication involved. It does not predict health risks unrelated to drug metabolism.
Will this test affect my medication choices?
Possibly. If you’re taking medications metabolized by CYP1A2, your provider may adjust dosages or choose alternatives to avoid potential side effects or reduced effectiveness. Always discuss this with your healthcare team.
Is this test covered by insurance?
Coverage depends on your reason for testing, location, and insurance plan. Carrier screening or prenatal tests may be covered if medically necessary, while routine genetic testing often requires prior authorization. Check with your insurance provider or provider’s office for details.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy