Skip to content

Endometrial Cytology (Cellular Analysis of the Uterine Lining)

Published: August 9, 2026Updated: August 16, 2026

This test examines cells collected from your uterine lining (endometrium) to check for abnormalities, such as signs of infection, inflammation, or precancerous changes.

Quick summary

["This test helps detect early signs of uterine health issues, including infections or potential cancer risks."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
55604-3
Short code
Cyto Endometrium
Synonyms
Cyto Endometrium
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
cyto-stain
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Endometrial Cytology Used For?

Endometrial cytology is primarily used to diagnose conditions affecting the uterine lining. It may be recommended if you have symptoms like abnormal vaginal bleeding, pelvic pain, or if you’re at higher risk for uterine abnormalities. This test can also help monitor conditions like endometrial hyperplasia or assess post-treatment outcomes in cases of known uterine issues.

How Is the Test Performed?

A healthcare provider collects cells from your uterine lining using a small brush or spatula during a procedure called a **dilation and curettage (D&C)** or sometimes through a simple swab during a pelvic exam. The cells are then analyzed under a microscope to identify any irregularities.

Preparation and Risks

No special preparation is needed, but you may be asked to avoid certain medications or procedures before the test. Common risks include mild cramping, bleeding, or infection, though serious complications are rare.

What Do Results Mean?

Results are interpreted by a pathologist and categorized into different classifications (e.g., normal, atypical, suspicious for malignancy). Abnormal findings may prompt further testing, such as additional biopsies or imaging, to investigate underlying causes.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Why might my doctor recommend this test?
Your doctor may suggest endometrial cytology if you have symptoms like unusual vaginal bleeding, persistent pelvic pain, or if you’re at higher risk due to factors like hormonal imbalances, prior uterine surgeries, or a family history of uterine cancer.
What happens if my test results are abnormal?
If your results show abnormalities, your doctor will discuss next steps, which may include additional tests like a biopsy, imaging studies, or further evaluation of your symptoms. Follow-up care depends on the specific findings and your overall health.
How often should I get this test?
The frequency depends on your medical history and symptoms. Your doctor will determine the best schedule based on your individual needs, such as whether you have a history of uterine issues or are undergoing treatment for a condition like endometrial cancer.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy