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Cytokine Profile in Urine (24-Hour Collection) – Kidney Function Assessment

Published: August 9, 2026Updated: August 16, 2026

This test measures certain signaling proteins (cytokines) in your urine over a 24-hour period. Cytokines help regulate immune responses and inflammation, and their presence in urine can provide insights into kidney health and inflammation.

Quick summary

["This test helps evaluate kidney function and inflammation linked to immune responses."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
31188-6
Short code
Cyto Kidney FNA
Synonyms
Cyto Kidney FNA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
136
Ref high
145
Critical range
120 N/A – 160 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
cyto-stain
CPT
84295
SNOMED
110741000
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like persistent swelling, unexplained protein in urine, or signs of kidney disease. It can also help assess conditions affecting kidney inflammation, such as certain autoimmune diseases or infections.

What to Expect Before the Test

You’ll need to collect all urine for a full 24-hour period in a special container. Drink plenty of fluids to ensure adequate urine production. Avoid certain medications or supplements that might interfere with results, as directed by your provider.

What the Test Measures

This test detects specific cytokines (e.g., interleukins, tumor necrosis factors) in urine, which are proteins involved in immune and inflammatory processes. Elevated levels may indicate kidney inflammation or other systemic conditions.

Common Conditions Monitored

This test is often used to monitor kidney inflammation in conditions like glomerulonephritis, interstitial nephritis, or other immune-mediated kidney diseases. It may also help track responses to treatments.

Reference range

Adult: 136-145 mmol/LN/A

Specimen: serum

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine Cytokine Panel

Frequently asked questions

How long does a 24-hour urine collection take?
A 24-hour urine collection requires collecting all urine produced over a full day, typically from one morning to the next. You’ll need to empty your bladder at the start and end of the period, discarding the first and last samples. Use a clean container provided by your lab to store the urine.
What should I do if I miss any urine during the collection?
If you miss urine, you should restart the collection immediately and document the missed time. Notify your healthcare provider or lab technician right away to avoid incomplete results. Drink extra fluids if needed to help complete the collection.
Can I take over-the-counter medications during the urine collection?
Some medications or supplements may interfere with cytokine measurements. Always check with your provider before taking any new medications, including pain relievers, anti-inflammatories, or herbal supplements, during your urine collection period.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy