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Dihydroxyphenylacetic acid (DHPAA) in urine

Published: August 9, 2026Updated: August 17, 2026

This test measures a breakdown product of certain brain chemicals, often linked to metabolic or neurological processes. It may be used to assess conditions involving neurotransmitter metabolism.

Quick summary

["This test helps evaluate metabolic pathways in the body, particularly those involving dopamine metabolism."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
102274-8
Short code
Daphnia IgE RAST
Synonyms
Daphnia IgE RAST
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
40
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
rast
CPT
84484
SNOMED
302774002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if they suspect an imbalance in brain chemicals, such as in conditions like Parkinson’s disease, certain neurological disorders, or metabolic disorders. It can also be part of broader screening for conditions affecting neurotransmitter levels.

What to Expect Before the Test

No special preparation is typically required. You may be asked to collect a urine sample in the morning, often after an overnight fast. Follow your healthcare provider’s instructions precisely.

How the Test Works

Urine is collected and analyzed to measure the concentration of dihydroxyphenylacetic acid. The test detects this chemical, which is a byproduct of dopamine metabolism, using a specialized laboratory method.

What the Results Mean

Results are interpreted by your healthcare provider based on your medical history, symptoms, and other test results. Elevated levels may suggest certain metabolic or neurological conditions, while normal levels help rule out specific disorders.

Reference range

Adult: 10-40 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Urine DHPAA

Frequently asked questions

How common is this test?
This test is less commonly performed than others but may be part of specialized evaluations for metabolic or neurological disorders. It is often used in research or when specific symptoms point toward dopamine-related conditions.
What are the typical reference ranges?
Reference ranges for this test are not widely standardized and may vary by lab. Your results will be compared to your specific lab’s reference values and clinical context.
Are there any risks or side effects?
There are no risks associated with this urine test. The process is simple and painless, involving only urine collection. If you have any concerns, discuss them with your healthcare provider before the test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy