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Complete Blood Count (CBC) with Differential and Platelet Count

Published: August 9, 2026Updated: August 17, 2026

This test measures key components of your blood, including red blood cells, white blood cells, and platelets, along with the proportions of different types of white blood cells.

Quick summary

["A CBC helps your doctor assess overall health, detect infections, anemia, or blood disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
58956-4
Short code
DAT C3b+C4d Comp-Sp Reag RBC Ql
Synonyms
DAT C3b+C4d Comp-Sp Reag RBC Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
4.2
Ref high
5.9
Critical range
2 N/A – 7 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85041
SNOMED
900000000000003001
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Blood Cells Are Measured?

Your blood contains several types of cells that play vital roles in health. This test evaluates red blood cells (RBCs), which carry oxygen; white blood cells (WBCs), which fight infections; and platelets, which help with clotting. The differential counts specific types of WBCs (neutrophils, lymphocytes, monocytes, eosinophils, basophils) to identify inflammation, infections, or other conditions.

How Is This Test Performed?

A small blood sample is taken from a vein, usually in your arm. The sample is analyzed to count and identify the different blood cells. This process helps determine if your blood cell counts are within normal ranges or if further investigation is needed.

Why Might You Need This Test?

A CBC is commonly ordered for routine check-ups, to monitor chronic conditions (like anemia or blood disorders), or to investigate symptoms such as fatigue, frequent infections, easy bruising, or unexplained bleeding.

What Could Abnormal Results Indicate?

Low red blood cell counts may suggest anemia, while high counts could indicate conditions like polycythemia. Low platelet counts might point to bleeding disorders, while high counts could signal clotting issues. Abnormal white blood cell counts can signal infections, inflammation, or autoimmune disorders.

Reference range

Adult males: 4.2-5.9; Females: 3.8-5.1 x 10^12/LN/A

Specimen: serum

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CBC with Differential

Frequently asked questions

Why do I need a CBC with differential if I feel healthy?
Even if you feel healthy, a CBC can detect subtle changes in your blood that might not cause symptoms. It’s often used for routine check-ups, especially if you have a family history of blood disorders or chronic conditions.
What does it mean if my white blood cell count is high?
A high white blood cell count can indicate an active infection, inflammation, or sometimes an underlying condition like cancer. Your doctor will review your symptoms and other test results to determine the cause.
Can I eat or drink anything before this test?
For most CBC tests, you can eat and drink normally. However, if your doctor has specific instructions (like fasting), follow them to ensure accurate results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy