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Serum or Plasma Creatinine Concentration (Substance Concentration)

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of creatinine, a waste product from muscle metabolism, in your blood or plasma. It helps assess kidney function by checking how well your kidneys filter blood.

Quick summary

["A creatinine test helps determine if your kidneys are working properly."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
55776-9
Short code
DAT IgG-Sp Reag RBC Ql
Synonyms
DAT IgG-Sp Reag RBC Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
4.2
Ref high
5.9
Critical range
2 N/A – 7 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85041
SNOMED
900000000000003001
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Creatinine is a byproduct of muscle breakdown and is normally filtered out by your kidneys. If your kidneys aren’t working well, creatinine levels can build up in your blood. This test is often used alongside other blood tests to evaluate kidney health, especially if you have symptoms like swelling, fatigue, or changes in urine output.

What to Expect During the Test

You’ll have a small needle inserted into your arm or vein to draw blood. The test is quick and usually done in a lab setting. No special preparation is needed unless your doctor instructs otherwise.

How the Results Are Used

Your doctor will compare your creatinine level to a reference range to see if it’s within normal limits. Elevated levels may suggest kidney problems, while lower levels could indicate muscle loss or other conditions. Creatinine is often used in combination with other tests, like blood urea nitrogen (BUN), to assess kidney function more accurately.

Common Causes of Abnormal Results

Creatinine levels can be affected by factors like dehydration, muscle mass, certain medications, or kidney disease. High levels may indicate poor kidney function, while very low levels might suggest dehydration or conditions that reduce muscle mass.

Reference range

Adult males: 4.2-5.9; Females: 3.8-5.1 x 10^12/LN/A

Specimen: serum

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Creatinine Level

Frequently asked questions

What does my creatinine level tell me about my health?
Your creatinine level helps doctors monitor kidney function. If your levels are consistently high, it may signal kidney damage or disease. If your levels are low, it could be due to factors like dehydration, low muscle mass, or certain medical conditions. Always discuss your results with your healthcare provider for personalized insights.
How often should I get this test?
Your doctor will determine how often you need this test based on your health status. People with kidney disease, diabetes, or high blood pressure may need more frequent testing. Regular check-ups can help catch issues early.
Can diet or lifestyle affect creatinine levels?
Yes, diet and lifestyle can influence creatinine levels. Eating foods high in protein or muscle-building supplements may temporarily raise levels. Staying hydrated helps maintain normal levels, but excessive fluid intake isn’t always recommended without medical guidance.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy