Serum/plasma protein electrophoresis with bromocresol green and bromocresol purple staining

What Does This Test Measure?

Protein electrophoresis separates blood proteins into distinct fractions based on size and charge. The test uses dyes (bromocresol green and purple) to visualize these fractions, allowing for detailed analysis of albumin, globulins, and other proteins. This process helps detect shifts in protein composition that may signal underlying health issues.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms like swelling, unexplained weight loss, fatigue, or if they suspect conditions such as multiple myeloma, liver disease, or kidney disease. It’s also used to monitor treatment progress for certain disorders.

Sample Collection and Preparation

A blood sample is drawn from a vein, typically in your arm. The blood is then processed to separate serum or plasma, which is sent to the lab for electrophoresis. No special preparation is needed, but fasting may be advised depending on your specific test instructions.

Common Conditions Monitored

This test can help identify conditions like hypoalbuminemia (low albumin), dysproteinemias (abnormal protein levels), or specific types of plasma cell dyscrasias (e.g., multiple myeloma). It may also assist in diagnosing or managing conditions like nephrotic syndrome or chronic liver disease.