Fetal Maternal Serum Alpha-Fetoprotein (AFP) with Polysaccharide Profile (Qualitative/Quantitative)
This test measures specific proteins and substances in your blood to assess fetal development and detect potential birth defects or chromosomal abnormalities.
["Helps monitor fetal health and screen for genetic conditions during pregnancy."]
Key facts at a glance
- LOINC
- 103598-9
- Short code
- DAT Poly-Sp Reag RBC Fetus Ql
- Synonyms
- DAT Poly-Sp Reag RBC Fetus Ql
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 4.2
- Ref high
- 5.9
- Critical range
- 2 N/A – 7 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 85041
- SNOMED
- 900000000000003001
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test includes a detailed analysis of alpha-fetoprotein (AFP) and other related substances, such as polysaccharides, which are markers for fetal development. AFP is a protein produced by the fetus and can be detected in the mother’s blood. The polysaccharide profile helps identify variations in these substances that may indicate developmental issues.
Why It’s Done During Pregnancy
This test is often performed during the first or second trimester to screen for conditions like neural tube defects (such as spina bifida) or chromosomal abnormalities (like Down syndrome). It may also be used to evaluate fetal maturity or monitor specific pregnancies with higher risk factors.
Sample Collection and Preparation
A blood sample is taken from your arm. The blood is processed to separate components, and the test measures the concentration or presence of AFP and related polysaccharides. Some tests may require a 24-hour urine collection for polysaccharide analysis.
Interpreting Results
Results are compared to established reference ranges for gestational age. Elevated or low levels of AFP or polysaccharides may signal potential concerns that your healthcare provider will discuss with you. Follow-up tests or additional imaging may be recommended if abnormalities are detected.
Reference range
Adult males: 4.2-5.9; Females: 3.8-5.1 x 10^12/LN/A
No special preparation required. Stay well hydrated.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Frequently asked questions
What does a high or low AFP level mean?
Does this test require fasting?
How soon will I receive my results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy