Skip to content

Cholesterol (Total) in Serum or Plasma by Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of cholesterol in your blood, which is an important part of your lipid profile. Cholesterol helps your body make hormones and cell membranes but can build up in your arteries if levels are too high.

Quick summary

["Your cholesterol levels help assess your risk for heart disease and other health conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
38739-9
Short code
DCP Air-mCnc
Synonyms
DCP Air-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors may order this test to check your overall cholesterol levels, monitor existing conditions like high cholesterol, or evaluate risk factors for heart disease, stroke, or diabetes. It’s often part of a broader lipid panel that also includes HDL, LDL, and triglycerides.

What Does the Test Involve?

A blood sample is taken from a vein, usually in your arm. The sample is sent to a lab where it’s analyzed to determine the total cholesterol concentration in your blood.

What to Expect Before or After the Test

There are usually no special preparations needed, but you may be asked to fast for 12 hours before the test if it’s part of a lipid panel. After the test, you’ll typically feel minor discomfort from the needle insertion, and you can resume normal activities immediately.

What Are the Results Typically Used For?

Results help doctors determine if your cholesterol levels are within a healthy range or if lifestyle changes, medications, or further testing are needed. High cholesterol can increase the risk of plaque buildup in your arteries, which may lead to heart disease or stroke.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: High Cholesterol Risks and Management

Short name

Total Cholesterol

Frequently asked questions

What does a high or low cholesterol level mean?
High cholesterol levels may indicate an increased risk of cardiovascular diseases, such as heart attack or stroke. Low cholesterol levels, while less common, can sometimes signal underlying health issues like liver disease or malnutrition. Your doctor will discuss your results in the context of your overall health.
How often should I get this test?
The frequency depends on your health status. Healthy adults may get tested every 4–6 years, while those with risk factors (like high blood pressure, diabetes, or a family history of heart disease) may need testing more often, often every 1–2 years. Your doctor will recommend the best schedule for you.
Can diet or lifestyle changes affect cholesterol levels?
Yes! Eating a balanced diet low in saturated and trans fats, exercising regularly, maintaining a healthy weight, and avoiding smoking can help improve cholesterol levels naturally. If lifestyle changes aren’t enough, your doctor may recommend medications like statins.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy