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D-dimer plasma mass concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of D-dimer, a protein fragment produced when blood clots break down. It helps assess whether you may have a blood clot or bleeding disorder.

Quick summary

["D-dimer helps guide decisions about blood clots or clot-related conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
48066-5
Short code
D Dimer PPP DDU-mCnc
Synonyms
D Dimer PPP DDU-mCnc
Category
coagulation
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ddu
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is D-dimer Used For?

D-dimer is primarily used to evaluate suspected blood clots (thrombosis) or conditions where clots may form, such as deep vein thrombosis (DVT) or pulmonary embolism. It can also help rule out certain bleeding disorders or complications from treatments that affect clotting.

How Is the Test Performed?

A blood sample is taken from a vein, usually in your arm. The blood is processed to separate plasma, and the D-dimer level is measured using a sensitive laboratory test that detects the protein fragments.

What Does a High or Low Level Mean?

A high D-dimer level often suggests recent clot formation, which may indicate conditions like DVT or pulmonary embolism. However, other factors—such as pregnancy, recent surgery, or certain medications—can also raise D-dimer levels. A low level usually means there is little to no recent clot activity.

When Might You Need This Test?

Your healthcare provider may order a D-dimer test if you have symptoms like swelling, pain in your legs (DVT), chest pain (possible pulmonary embolism), or if you’ve been diagnosed with a clotting disorder or are taking blood thinners.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

D-dimer

Frequently asked questions

Why might my D-dimer test result be abnormal even if I don’t have a clot?
Abnormal results can occur due to factors like pregnancy, recent surgery, infections, or certain medications that affect clotting. Your healthcare provider will consider your full medical history and symptoms.
What should I do if my D-dimer level is high?
If your D-dimer level is elevated, your doctor may recommend additional tests (like imaging) to check for clots or further evaluate your symptoms. Treatment may be needed if a clot is confirmed.
Can diet or supplements affect D-dimer levels?
Some supplements or medications (like warfarin or low-dose aspirin) can influence clotting. Always discuss any supplements or medications with your provider before testing, as they may affect results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy