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D-dimer plasma mass concentration (quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of D-dimer, a protein fragment produced when blood clots break down. It helps assess the risk of blood clots or conditions like deep vein thrombosis or pulmonary embolism.

Quick summary

["D-dimer helps identify possible blood clot risks or rule them out in certain situations."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
48058-2
Short code
D Dimer PPP IA.DDU-mCnc
Synonyms
D Dimer PPP IA.DDU-mCnc
Category
coagulation
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia-ddu
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for signs of blood clots, especially if you have symptoms like swelling, pain, or shortness of breath. It can also be used to evaluate conditions like deep vein thrombosis (DVT) or pulmonary embolism (PE). Sometimes, it’s part of a screening or diagnostic process for other blood-related issues.

What Does a High or Low Level Mean?

A high D-dimer level often suggests recent clot formation, which can guide treatment decisions. However, a normal result doesn’t always mean you don’t have a clot—it may just mean no significant breakdown of clots was detected at the time of testing. False positives can occur, so results should be reviewed by a healthcare provider.

How Is This Test Performed?

A small blood sample is drawn from a vein, usually in your arm. The plasma portion is tested for D-dimer using a sensitive laboratory method to detect its presence.

What Are Common Causes of Abnormal Results?

Elevated D-dimer levels can be caused by active blood clots, certain cancers, infections, or other conditions that increase clot breakdown. Low levels may be normal or could indicate conditions like severe bleeding or certain blood disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

D-dimer is primarily used as a screening or diagnostic tool to support the evaluation of suspected blood clots. While it’s not definitive on its own, it helps narrow down possibilities when combined with clinical findings and other tests. It’s also used in monitoring certain patients (e.g., those with cancer or recent surgery) to assess clot risks over time.

Short name

D-dimer

Frequently asked questions

What does a positive D-dimer test mean?
A positive D-dimer test indicates the presence of clot breakdown products, which may suggest recent clot formation. However, it doesn’t confirm a clot without further evaluation. Your provider will consider your symptoms, medical history, and other test results to guide next steps.
Can D-dimer levels change over time?
Yes, D-dimer levels can fluctuate depending on factors like recent clot activity, medications, or underlying health conditions. If you’re being monitored for blood clots, your provider may retest to track changes over time.
Is this test safe?
Yes, this blood test is generally safe. The risk of complications from a small blood draw is minimal, and no special preparation is usually needed beyond avoiding certain medications or foods for a short time if instructed.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy