DDIT3 Gene Rearrangement — Blood, Fluorescence In Situ Hybridization (FISH)
A specialized FISH test that looks for rearrangement of the DDIT3 gene in blood cells to help evaluate certain possible cancer-related genetic changes.
["This test checks whether the DDIT3 gene has been rearranged, a finding that can occur in certain tumors."]
Key facts at a glance
- LOINC
- 101379-6
- Short code
- DDIT3 gene rearrangement Bld/T FISH
- Synonyms
- DDIT3 gene rearrangement Bld/T FISH
- Category
- thyroid
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Ref low
- 80
- Ref high
- 200
- Critical range
- 20 N/A – 400 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- fish
- CPT
- 84436
- SNOMED
- 302346007
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This is a specialized genetic test performed on blood using fluorescence in situ hybridization, or FISH. It uses fluorescent DNA probes to look for rearrangement of the DDIT3 gene, which encodes a protein involved in cellular stress responses.
Why might I need this test?
This test may be ordered as part of an evaluation for a suspected cancer or to examine suspicious cells found in the blood. Rearrangement of DDIT3 is associated with some tumors, particularly forms of liposarcoma, but the result must be considered with the other test findings.
How is the test performed?
A blood sample is collected and prepared for FISH analysis. DNA from the submitted cells is examined with fluorescent probes designed to detect the location and arrangement of the DDIT3 gene. A qualified laboratory professional interprets the result.
How do I prepare for the test?
No special preparation is usually needed beyond following the laboratory's blood collection instructions. Fasting is generally not required, and you should not stop taking medicines unless your healthcare professional specifically tells you to do so.
Reference range
Adult: 80-200 ng/dLN/A
Take your thyroid medication after the blood draw if applicable. No fasting required.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
A detected DDIT3 gene rearrangement may support the presence of a certain tumor, including a liposarcoma, when combined with pathology and other clinical findings. A negative result does not completely exclude a rearrangement because the test depends on the specific DNA changes and the quality of the specimen. Results should be interpreted by a pathologist or other qualified clinician in the context of the entire evaluation.
Short name
DDIT3 Gene Rearrangement (FISH)
Frequently asked questions
What does a DDIT3 gene rearrangement mean?
Does this test diagnose cancer by itself?
Is this the same as an inherited DDIT3 genetic test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy