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Total Protein with Albumin-to-Globulin Ratio (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures your blood’s total protein levels and compares albumin (the protein that helps maintain fluid balance) to globulins (proteins involved in immunity and clotting).

Quick summary

["Understanding your protein balance can help identify issues like inflammation, kidney problems, or malnutrition."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
16765-0
Short code
DDT Mlk-mCnc
Synonyms
DDT Mlk-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

Total protein includes albumin and globulin, which are key proteins in your blood. Albumin helps distribute fluids and carry nutrients, while globulins support immune function and blood clotting. This test provides a ratio to assess protein distribution.

Why Might You Need This Test?

Doctors may order this test to diagnose or monitor conditions like chronic kidney disease, liver disease, infections, or malnutrition. The ratio can also help evaluate how well your body is retaining proteins.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where it is analyzed to measure total protein and the albumin-to-globulin ratio.

What Are Common Results?

Results are typically reported as a ratio (e.g., albumin:globulin) rather than absolute values. Abnormal ratios may signal underlying health concerns that need further investigation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Protein Balance and Health

Short name

Protein & Globulin Ratio

Frequently asked questions

How can I prepare for this test?
No special preparation is needed, but avoid heavy meals or excessive alcohol before your blood draw. Follow your healthcare provider’s instructions if you’re on certain medications.
Will I feel any discomfort?
You may feel a slight pinch when the needle is inserted, but most people describe it as mild. The area may tingle or bruise slightly afterward.
How long will it take to get my results?
Results are usually available within a few days to a week, depending on your lab’s processing time. Your doctor will discuss them with you during your follow-up.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy