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Cerebrospinal Fluid (CSF) Protein Profile (Qualitative or Semi-Quantitative Analysis)

Published: August 9, 2026Updated: August 16, 2026

This test examines the protein composition in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord) to help assess conditions affecting the central nervous system.

Quick summary

["Protein analysis in CSF can help diagnose or monitor neurological disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
104134-2
Short code
Dementia eval pnl CSF
Synonyms
Dementia eval pnl CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Ref low
44
Ref high
147
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84075
SNOMED
27550007
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What This Test Measures

CSF protein testing typically looks for the presence, pattern, and relative amounts of various proteins. This may include albumin, immunoglobulins (such as IgG), and other proteins that can indicate inflammation, infection, or structural damage in the brain or spinal cord.

Common Uses and Conditions

This test is often used to evaluate conditions like multiple sclerosis, meningitis, encephalitis, brain tumors, or other neurological diseases where protein abnormalities in CSF may be present.

Sample Collection and Preparation

A lumbar puncture (spinal tap) is performed to collect CSF. The fluid is then analyzed in a laboratory to identify protein patterns, which may require specialized techniques like electrophoresis or immunoassays.

When to Expect Results

Results may be reported qualitatively (presence or absence of certain proteins) or semi-quantitatively (relative amounts). Interpretation depends on clinical context and may take several days to a week.

Reference range

Adult: 44-147 U/LN/A

Specimen: csf

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Protein Evaluation

Frequently asked questions

Why might my doctor order this test?
Your doctor may recommend this test if you have symptoms like headaches, neurological deficits, seizures, or signs of brain inflammation/infection. It helps rule out or confirm conditions affecting the central nervous system.
How long does it take to get results?
Results can take from a few days to a week, depending on laboratory processing and reporting methods. Your healthcare provider will discuss findings with you during follow-up.
Is there any preparation needed before the test?
No special preparation is required, but you may be asked to avoid certain medications or activities for a short time before the lumbar puncture. Always follow your doctor’s instructions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy