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Substance concentration of immunoglobulin G (IgG) in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Immunoglobulin G (IgG), a type of antibody in your blood. IgG helps protect your body from infections and diseases.

Quick summary

["IgG levels help assess immune function and identify potential deficiencies or excesses."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
95673-0
Short code
DENV1+2+3+4 IgG Spec Ql IA
Synonyms
DENV1+2+3+4 IgG Spec Ql IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does IgG Measure?

IgG is the most abundant antibody in your blood, playing a critical role in fighting infections. It’s produced by your immune system to neutralize bacteria and viruses. Measuring IgG helps doctors evaluate your immune response, especially in conditions like HIV, autoimmune diseases, or after vaccination.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms of a weakened immune system (like frequent infections), suspected immunodeficiency, or if you’re being treated for conditions like lupus or other autoimmune disorders. It can also be used to monitor immune response after vaccination or during pregnancy.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. The blood is then processed to separate the serum or plasma, where the IgG antibody is measured using a specialized immunoassay technique. The result is compared to standard levels to determine your IgG concentration.

What Are Possible Results?

Results are expressed in grams per deciliter (g/dL) or milligrams per deciliter (mg/dL). While reference ranges vary by lab, lower than expected levels may indicate immunodeficiency, while higher levels could suggest conditions like multiple myeloma or chronic infections.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Low IgG levels may indicate a compromised immune system, increasing susceptibility to infections. High IgG levels can be seen in chronic infections, autoimmune diseases, or certain cancers. Monitoring IgG is particularly important for patients with HIV, those undergoing chemotherapy, or those with genetic immune disorders like Common Variable Immunodeficiency (CVID).

Short name

IgG Level

Frequently asked questions

What causes low IgG levels?
Low IgG levels can result from primary immune deficiencies (like CVID), chronic illnesses (such as HIV or liver disease), malnutrition, or certain medications that suppress the immune system. It may also occur in premature infants or those with autoimmune conditions.
What causes high IgG levels?
High IgG levels are often linked to chronic infections (like hepatitis or tuberculosis), autoimmune diseases (such as rheumatoid arthritis or lupus), or certain cancers (like multiple myeloma). Rarely, it can be due to overproduction of antibodies in response to repeated infections or vaccinations.
How often should I get this test?
Your doctor will determine the frequency based on your medical condition. If you have an ongoing immune-related issue, tests may be repeated every few months or as needed to monitor changes in your IgG levels.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy