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Zika Virus Immunoglobulin G (IgG) Antibody, Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies in your blood that your immune system produces in response to the Zika virus. It helps determine if you’ve been exposed to the virus in the past.

Quick summary

IgG antibodies can stay in your blood for months or even years after infection, aiding long-term detection of past exposure.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
87438-8
Short code
DENV1-4 + Zika IgA+IgG+IgM Spec IA-Imp
Synonyms
DENV1-4 + Zika IgA+IgG+IgM Spec IA-Imp
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test detects IgG antibodies specific to the Zika virus. These antibodies develop after your body has encountered the virus, typically within weeks to months after infection. They serve as a marker for past exposure rather than an immediate indicator of current infection.

Why Might You Need This Test?

Healthcare providers may order this test if you have symptoms suggestive of Zika virus infection (e.g., fever, rash, joint pain) and recent travel to or residence in an area with active Zika transmission. It may also be used as part of a broader evaluation for congenital Zika syndrome in pregnant individuals or those considering pregnancy.

How Is This Test Performed?

A blood sample is drawn from a vein in your arm. The serum portion of the blood is then tested using an immunoassay method to identify Zika-specific IgG antibodies. The process is typically completed within a few days.

What Are Possible Results?

Results are qualitative (positive, negative, or indeterminate). A positive result suggests past exposure to the Zika virus, while a negative result indicates no detectable IgG antibodies at the time of testing. An indeterminate result may require further testing or follow-up.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Zika IgG Antibody

Frequently asked questions

Why is it important to know if I had Zika in the past?
Knowing your past exposure to Zika can inform decisions about travel, pregnancy planning, or public health precautions. It also helps healthcare providers monitor long-term health effects, especially in individuals with weakened immune systems or those who may have experienced severe illness.
Can this test detect Zika infection right now?
No, this test specifically measures IgG antibodies, which develop after the initial infection and can persist for months. For detecting current infection, other tests (such as Zika virus RNA testing) are typically used.
What if my test result is positive?
A positive IgG result means you likely had Zika in the past. Your doctor may recommend additional testing or follow-up if you have concerns about current health, recent travel, or pregnancy planning. They can also discuss next steps based on your medical history and symptoms.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy