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Serum or Plasma Albumin to Globulin Ratio (A/G Ratio)

Published: August 9, 2026Updated: August 16, 2026

This test measures the ratio of albumin and globulin proteins in your blood, which helps assess protein balance and potential liver or kidney issues.

Quick summary

["A/G ratio helps identify protein imbalances that may signal underlying health conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
22252-1
Short code
DENV3 Ab Ser Ql
Synonyms
DENV3 Ab Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order an A/G ratio test to evaluate conditions affecting protein levels, such as liver disease, kidney problems, or malnutrition. It can also help diagnose or monitor chronic diseases like cirrhosis or chronic kidney disease.

What to Expect Before the Test

No special preparation is needed. You may have a simple blood draw, and results are typically ready within a few days.

What the Results Mean

A higher albumin-to-globulin ratio often suggests low globulin levels (e.g., due to liver dysfunction), while a lower ratio may indicate high globulin levels (e.g., from chronic inflammation or infection). Results are interpreted by your provider in the context of your overall health.

Common Conditions Monitored

This test is often used to monitor liver disease (like cirrhosis), chronic kidney disease, or conditions causing chronic inflammation (e.g., rheumatoid arthritis). It may also help assess nutritional status or response to treatment.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: An abnormal A/G ratio can signal underlying protein disorders, immune system dysfunction, or organ impairment, guiding treatment decisions for chronic conditions.

Short name

Albumin-to-Globulin Ratio

Frequently asked questions

What causes an abnormal A/G ratio?
Factors like liver disease, kidney problems, malnutrition, chronic infections, or autoimmune conditions may lead to elevated or low ratios. Your provider will review your medical history and other test results for a full picture.
How often should I get this test?
Frequency depends on your health condition. If you have a chronic illness (e.g., liver disease), your provider may recommend periodic testing to track changes. Follow their guidance for timing and intervals.
Can diet affect A/G ratio results?
Dietary changes (e.g., protein intake) may influence protein levels, but results are typically interpreted in the context of your overall health. Avoid extreme dietary shifts before testing unless advised by your provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy