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Serum or plasma concentration of digoxin (digitalis glycoside)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of digoxin, a medication used to treat certain heart conditions, in your blood. It helps ensure you’re taking the right dose and avoids harmful levels.

Quick summary

["Digoxin helps regulate your heart’s rhythm; too much can cause dangerous side effects."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
41878-0
Short code
DENV IgG+IgM Pnl Ser IA
Synonyms
DENV IgG+IgM Pnl Ser IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Digoxin is prescribed to manage conditions like irregular heartbeats (arrhythmias) or heart failure. Your doctor may order this test to check if your medication is working properly or if you’re experiencing too much of it.

How the Test Works

A small blood sample is taken, usually from your arm. The lab then measures the amount of digoxin in your serum or plasma using an immunoassay method, which detects the medication’s presence without needing a specific reference range.

What to Expect Before the Test

There are no special preparations needed. You may have a slight bruise or pinch at the injection site, but this is normal. If you’re on other medications, let your doctor know—some drugs (like certain antibiotics or diuretics) can affect digoxin levels.

Possible Results & Next Steps

Results are typically reported as a concentration value (e.g., micrograms per liter). Your doctor will interpret this in relation to your symptoms, other medications, and medical history. If levels are too high, they may adjust your dose or monitor you closely.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Digoxin Level

Frequently asked questions

What could cause abnormal results?
High digoxin levels may cause nausea, vomiting, irregular heartbeat, or vision changes. Low levels might mean your medication isn’t working well, so your doctor could increase your dose. Conditions like kidney disease can also affect how digoxin is processed in your body.
How often should I get this test?
Your doctor will determine the timing based on your treatment plan. For example, if you’re taking digoxin long-term, they may check levels every few months or as needed to adjust your dose.
Can I eat or drink before the test?
You can eat and drink normally before the test, as it doesn’t require fasting. However, if you’re on a specific diet or have other health instructions, follow your doctor’s advice.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy