Skip to content

Deoxyguanosine in Cerebrospinal Fluid (CSF)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of deoxyguanosine, a breakdown product of DNA, in your spinal fluid. It may be used to assess certain neurological conditions.

Quick summary

["This test helps evaluate DNA metabolism in your brain and spinal fluid."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
75149-5
Short code
Deoxyguanosine CSF-sCnc
Synonyms
Deoxyguanosine CSF-sCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why Might This Test Be Ordered?

Your healthcare provider may order this test if they suspect conditions affecting DNA breakdown or neurological disorders, such as certain types of encephalitis, metabolic disorders, or genetic conditions. It might also be part of a broader evaluation for unexplained neurological symptoms or genetic testing.

What Does the Sample Look Like?

A small amount of cerebrospinal fluid is collected through a procedure called a lumbar puncture (spinal tap). This fluid is typically clear or slightly cloudy and is sent to the lab for testing.

What Does the Test Involve?

The lab uses a specialized method (likely high-performance liquid chromatography or a similar technique) to measure the concentration of deoxyguanosine in your spinal fluid sample. No special preparation is needed, but you may need to stay still for a short time after the procedure.

What Are Common Reasons for Abnormal Results?

Elevated levels of deoxyguanosine in CSF might be associated with increased DNA turnover, which can occur in conditions like certain infections, metabolic disorders, or genetic diseases. However, interpretation depends on clinical context and other test results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Deoxyguanosine levels in CSF can provide insights into DNA metabolism and potential neurological or systemic disorders. While not always definitive on its own, it may be part of a diagnostic workup for conditions affecting the central nervous system or genetic disorders. Always discuss results with your healthcare provider.

Short name

Deoxyguanosine CSF

Frequently asked questions

What does a high or low level of deoxyguanosine in CSF mean?
High levels may suggest increased DNA breakdown, which can occur in conditions like certain infections, metabolic disorders, or genetic diseases. Low levels alone are less commonly evaluated but could be part of a broader assessment if other symptoms or findings are present.
How is this test different from other DNA-related tests?
This test specifically measures deoxyguanosine in spinal fluid, unlike blood-based DNA tests (e.g., for cell-free DNA). It focuses on the breakdown products of DNA within the central nervous system, offering a different perspective on neurological health.
Do I need to prepare for this test?
No special preparation is required, but you may need to fast or avoid certain medications as directed by your provider before the lumbar puncture. Follow your healthcare provider’s instructions for the day of the test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy