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Cerebrospinal Fluid Protein Mass Concentration (Total Protein)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord). Protein levels can help diagnose conditions affecting the central nervous system.

Quick summary

["Protein in CSF may indicate inflammation, infection, or other neurological issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
16357-6
Short code
Deprecated AB-Gp CSF-mCnc
Synonyms
Deprecated AB-Gp CSF-mCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like headaches, neck stiffness, confusion, or neurological problems. It’s also used to monitor conditions such as multiple sclerosis, meningitis, or brain tumors.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your back to collect a small amount of CSF. You may feel a brief pinch, but it’s usually over quickly. Rest for a few minutes afterward.

What Happens During the Test

The test involves a lumbar puncture (spinal tap), where fluid is taken from your lower spine. The lab analyzes the protein content in the collected sample.

What the Results Mean

Elevated protein levels in CSF can signal conditions like infections, autoimmune diseases, or tumors. Lower-than-normal levels may suggest certain genetic disorders or metabolic issues.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Protein Level

Frequently asked questions

What causes elevated protein levels in CSF?
Elevated protein levels in CSF can result from inflammation, infections (like meningitis), demyelinating diseases (such as multiple sclerosis), or tumors. Your provider will consider your symptoms and other test results to determine the cause.
Can diet or lifestyle affect this test?
Diet or lifestyle changes typically do not directly affect CSF protein levels, as this fluid is produced by the brain and spinal cord. However, hydration status may influence fluid volume but not protein concentration.
How often should this test be repeated?
Your provider will decide how often to repeat this test based on your symptoms, diagnosis, and treatment plan. Follow-up may be needed if initial results suggest an ongoing condition requiring monitoring.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy