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Plasma or Serum Creatinine Concentration (Mass)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of creatinine, a waste product from muscle breakdown, in your blood or plasma. It helps assess kidney function.

Quick summary

["Kidney health and function depend on this test."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
16356-8
Short code
Deprecated AB-Gp Plas-mCnc
Synonyms
Deprecated AB-Gp Plas-mCnc
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check how well your kidneys are filtering waste from your blood. It can help diagnose or monitor kidney disease, track kidney function over time, or evaluate conditions affecting kidney function, such as dehydration, heart failure, or certain medications.

What to Expect Before the Test

No special preparation is needed for this blood test. You may be asked to fast for 8–12 hours before the test if it’s part of a broader metabolic panel, but this is not always required. Drink plenty of water the day before if you’re dehydrated.

What Happens During the Test?

A healthcare professional will draw blood from a vein in your arm using a small needle. You may feel a brief pinch, but it usually doesn’t cause significant discomfort. The blood is then sent to a lab for analysis.

What Are the Results Mean?

Higher than expected levels may suggest kidney problems, while lower levels could indicate muscle breakdown or certain liver conditions. Your doctor will interpret results in the context of your overall health and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Creatinine levels are a key indicator of kidney function because it’s a byproduct of muscle metabolism and is filtered out by the kidneys. Elevated levels often signal impaired kidney function, including chronic kidney disease, acute kidney injury, or other conditions that affect blood flow to the kidneys. Regular monitoring of creatinine can help detect early kidney issues, allowing for timely medical intervention.

Short name

Creatinine Level

Frequently asked questions

How often should I get this test?
The frequency depends on your health status. If you have kidney disease, diabetes, or other conditions that affect kidneys, your doctor may recommend testing every few months or annually. Healthy individuals may only need baseline testing if they have risk factors (e.g., high blood pressure, family history).
What can affect my creatinine levels?
Several factors can influence creatinine levels, including muscle mass (higher muscle = higher creatinine), dehydration, certain medications (e.g., NSAIDs, contrast dyes), or conditions like heart failure or liver disease. Your doctor will consider these when reviewing your results.
Do I need to avoid certain foods or drinks before this test?
No special diet is required, but avoid excessive protein intake the day before if your test is part of a metabolic panel. Drinking water normally is fine unless your doctor advises otherwise.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy