Skip to content

Beta-Lactoglobulin IgG Antibody, Qualitative (RAST)

Published: August 9, 2026Updated: August 17, 2026

A qualitative blood test for IgG antibodies to beta-lactoglobulin, a cow's-milk protein. Results require clinical context and do not alone diagnose milk allergy.

Quick summary

["A positive result shows IgG antibodies to beta-lactoglobulin but does not by itself confirm a milk allergy."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
21109-4
Short code
Deprecated B-Lactoglob IgG RAST Ql
Synonyms
Deprecated B-Lactoglob IgG RAST Ql
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
40
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84484
SNOMED
302774002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This test checks your blood for IgG antibodies directed against beta-lactoglobulin, a protein found in cow's milk. It reports whether such antibodies are detected rather than providing a specific concentration.

Why might I need this test?

A clinician may order this test when evaluating possible reactions to milk or milk-containing foods. It may also be used to assess immune exposure to beta-lactoglobulin.

How is the test performed?

A blood sample is analyzed using a RAST-type laboratory method, which determines whether IgG antibodies bind to beta-lactoglobulin. The result is reported as detected or not detected.

How do I prepare for the test?

No special preparation is usually required for this qualitative antibody test. Follow any instructions from your clinician, and tell the laboratory if you have recently eaten dairy products or started a new medication.

Reference range

Adult: 10-40 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Detected IgG antibodies may indicate previous exposure or an immune response to beta-lactoglobulin. However, food-specific IgG results are not a reliable stand-alone measure of clinical allergy and can occur in people without symptoms. A result should therefore be interpreted by your clinician alongside your symptoms, diet, and any other allergy testing.

Short name

Beta-lactoglobulin IgG antibody

Frequently asked questions

Does a positive result mean I am allergic to milk?
Not necessarily. Detected IgG antibodies can indicate exposure or sensitization, but this result alone does not confirm a clinical milk allergy. Your clinician should interpret it in the context of your symptoms and medical history.
What is beta-lactoglobulin?
Beta-lactoglobulin is a protein found in cow's milk and may also be present in products made from milk. Heating can change the protein and affect how the immune system responds to it.
Is this the same as a milk-specific IgE test?
No. This test looks for IgG antibodies, while milk-specific IgE testing evaluates a different type of immune response that is more closely associated with immediate allergic reactions. Your clinician can advise which test is appropriate for your situation.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy