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Cystatin C, Serum Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of cystatin C, a protein produced by all cells in the body that helps regulate cell growth. It’s often used to assess kidney function.

Quick summary

["Cystatin C helps evaluate kidney health and may support the diagnosis of kidney disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
42142-0
Short code
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Synonyms
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Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
mam
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order a cystatin C test to check how well your kidneys are working. It can be useful for monitoring kidney function, especially in people with conditions like diabetes or high blood pressure that can affect the kidneys. Cystatin C is also sometimes used alongside other tests to help determine if you have kidney disease or to guide treatment decisions.

How Is the Sample Collected?

A blood sample is taken from a vein, usually in your arm. You may feel a small pinch when the needle is inserted, but the procedure is quick. The blood is collected in a special tube and sent to the lab for testing.

What Do the Results Mean?

Higher than expected levels of cystatin C may indicate kidney problems or other health conditions. Lower levels might suggest kidney function is better than expected. Your doctor will interpret your results in the context of your overall health and other tests.

Common Conditions Monitored

Cystatin C is often used alongside creatinine tests to assess kidney function. It can help detect early signs of kidney disease, especially in people who don’t have symptoms yet. It’s also useful for monitoring kidney function in people with chronic conditions like diabetes or heart disease.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cystatin C

Frequently asked questions

Why might my doctor want to check my cystatin C level?
Your doctor may recommend this test if you have risk factors for kidney disease, such as high blood pressure, diabetes, or a family history of kidney problems. It can also be used to monitor kidney function during treatment for conditions like lupus or certain cancers.
How often should I get this test?
The frequency depends on your health and any conditions you have. Your doctor will let you know how often to get tested, whether it’s once a year or more often if needed.
Can I eat or drink anything before this test?
No special preparation is usually needed for this test. You can eat and drink normally, but it’s always best to follow your doctor’s instructions for your specific test.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy