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Serum Protein Electrophoresis (Albumin and Immunoglobulins), Qualitative — Deprecated Category Test

Published: August 9, 2026Updated: August 17, 2026

A historical qualitative test that separates serum proteins to assess albumin and immunoglobulin patterns. It has been replaced by more specific protein testing methods.

Quick summary

["This deprecated test evaluates the pattern of albumin and immunoglobulins in serum but should not be interpreted without the current protein test results."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
25585-1
Short code
Deprecated Cat Serum Alb IgE RAST Ql
Synonyms
Deprecated Cat Serum Alb IgE RAST Ql
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
40
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84484
SNOMED
302774002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This is a qualitative serum protein electrophoresis test that separates proteins in blood serum into groups. It provides a general picture of the albumin and immunoglobulin bands rather than precise measurements of each protein.

Why might I need this test?

It may have been used to investigate an unusual blood protein pattern or possible monoclonal protein. It has generally been replaced by quantitative protein measurements, immunofixation, or other more specific laboratory methods.

How is the test performed?

A blood sample is collected, and the serum is separated from the cells. The laboratory then uses electrophoresis to separate the serum proteins and reports the presence or pattern of albumin and immunoglobulin bands.

How do I prepare for the test?

Fasting is usually not required. Tell your clinician about recent intravenous immunoglobulin treatment, because administered antibodies can temporarily alter the protein pattern. Follow any preparation instructions provided with the test order.

Reference range

Adult: 10-40 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

An abnormal electrophoretic pattern may occur with inflammation, liver disease, kidney disease, or a monoclonal protein disorder. Because this is a deprecated qualitative category test, the result should be interpreted alongside current quantitative protein results, symptoms, and other appropriate testing.

Short name

Qualitative Serum Protein Electrophoresis

Frequently asked questions

Is this still the usual way to evaluate serum proteins?
No. This category test is deprecated, and current laboratory evaluation more often uses quantitative protein measurements, immunofixation, and targeted antibody tests.
Does a qualitative result provide exact protein levels?
No. It primarily describes the pattern of separated proteins and is not a substitute for quantitative albumin or immunoglobulin measurements.
Can intravenous immunoglobulin affect the result?
Yes. Recently administered intravenous immunoglobulin can produce unusual immunoglobulin bands, so the laboratory and ordering clinician should be told about this treatment.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy