Skip to content

Alpha-1 Antitrypsin (Serum) Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of Alpha-1 Antitrypsin, a protein produced primarily in the liver that helps protect lung tissue from damage caused by enzymes released during inflammation.

Quick summary

["A1AT levels help assess lung and liver health, especially in conditions like emphysema or chronic liver disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
10440-6
Short code
Deprecated CD30 Ag Tiss Ql ImStn
Synonyms
Deprecated CD30 Ag Tiss Ql ImStn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
immune-stain
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Alpha-1 Antitrypsin plays a critical role in preventing lung damage. Low levels may indicate genetic disorders or liver disease, which can lead to serious complications like emphysema or cirrhosis.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if your doctor specifies it. Bring any medications you’re currently taking.

How the Test Is Performed

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab for analysis using an immunoassay method to measure your A1AT protein concentration.

Possible Results and Interpretation

Results are compared to standard reference ranges, but exact values depend on lab protocols. Low levels may signal genetic mutations (e.g., alpha-1 antitrypsin deficiency), while normal or high levels suggest healthy protein production.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Alpha-1 Antitrypsin (A1AT)

Frequently asked questions

What could my A1AT test results mean?
Low A1AT levels are strongly linked to alpha-1 antitrypsin deficiency, a genetic condition that increases lung disease risk. Your doctor may recommend further testing or monitoring if results are below normal.
How often should I get this test?
Your doctor will determine frequency based on your symptoms, medical history, or risk factors. Regular monitoring may be advised if you have a family history of lung disease or liver issues.
Can I adjust my diet before this test?
No dietary restrictions apply unless your doctor instructs otherwise. Focus on hydration and avoid alcohol, as it may affect liver function and indirectly influence protein levels.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy