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Alpha-1 Antitrypsin (A1AT) Serum/Plasma Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Alpha-1 Antitrypsin, a protein that helps protect your lungs and liver from damage caused by enzymes released during inflammation.

Quick summary

["A1AT helps prevent lung diseases like emphysema and liver conditions like cirrhosis."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46353-9
Short code
Deprecated Chest XR PA+Lat+Obl
Synonyms
Deprecated Chest XR PA+Lat+Obl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like chronic coughing, shortness of breath, or unexplained liver issues. It’s also used to monitor conditions like alpha-1 antitrypsin deficiency, which can lead to lung or liver disease over time.

What to Expect During the Test

A simple blood sample is taken from a vein, usually in your arm. You may feel a small pinch, but it’s quick and doesn’t require special preparation.

Common Conditions Monitored

Low levels of A1AT can be linked to genetic disorders or chronic lung diseases. High levels may indicate liver disease or certain inflammatory conditions.

How Results Are Used

Your results help doctors diagnose or manage conditions like alpha-1 antitrypsin deficiency, chronic obstructive pulmonary disease (COPD), or liver disorders by tracking protein levels over time.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Alpha-1 Antitrypsin Deficiency

Short name

Alpha-1 Antitrypsin Level

Frequently asked questions

What might cause abnormal results?
Abnormally low A1AT levels are most commonly associated with alpha-1 antitrypsin deficiency, a genetic disorder. Other causes may include chronic liver disease, certain medications, or conditions like cystic fibrosis. High levels could suggest liver disease or acute inflammation.
How long will I need to wait for results?
Results are typically available within 1 to 3 business days, depending on your lab. Your doctor will contact you once they’re ready.
Can I prepare for this test?
No special preparation is needed. However, avoid heavy meals or alcohol before the blood draw if your doctor advises it.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy