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Cryoglobulins (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of abnormal proteins called cryoglobulins in your blood. These proteins may clump together when the blood cools, potentially causing symptoms or complications.

Quick summary

["Cryoglobulins can indicate underlying conditions that may affect your immune system or blood flow."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
33272-6
Short code
Deprecated Cryoglob Ser Ql
Synonyms
Deprecated Cryoglob Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
d-cold-incubation
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Are Cryoglobulins?

Cryoglobulins are abnormal proteins found in your blood that can form clumps (precipitates) when exposed to lower temperatures. These clumps can block small blood vessels, leading to symptoms like swelling, pain, or skin changes. They are often linked to immune system disorders or infections.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms such as joint pain, rash, fatigue, or unexplained swelling. It’s also used to monitor conditions like lupus, rheumatoid arthritis, or hepatitis-related immune issues where cryoglobulins are suspected.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The blood is then sent to a lab where it’s analyzed to detect abnormal proteins that form clumps when cooled.

What Could Affect Results?

Factors like recent infections, certain medications, or existing immune conditions may influence cryoglobulin levels. Avoiding certain foods or supplements for a few days before testing can sometimes improve accuracy.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cryoglobulin Screen

Frequently asked questions

What does a positive result mean?
A positive result suggests the presence of abnormal proteins that may form clumps in cold temperatures. This can indicate an underlying immune disorder or other conditions requiring further evaluation by your doctor.
How often should I get this test?
Your doctor will determine the frequency based on your symptoms, medical history, and treatment plan. Follow-up tests may be needed if you have ongoing symptoms or if your condition is being monitored.
Can lifestyle changes help with cryoglobulins?
While lifestyle changes alone won’t change cryoglobulin levels, managing conditions like infections, stress, or certain medications under medical supervision may help reduce symptoms or slow disease progression.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy