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Bone Biopsy: Cortical Bone Mineral Density (Bone Mineral Content)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of mineral content in a small sample of your bone tissue, specifically the dense outer layer (cortical bone), to assess bone health and density.

Quick summary

["Helps evaluate bone strength and identify potential risks of osteoporosis or other bone-related conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
43568-5
Short code
Deprecated CT Bone Deep biopsy guide
Synonyms
Deprecated CT Bone Deep biopsy guide
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ct
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

A biopsy sample of your cortical bone is analyzed to determine its mineral density. This process helps identify how much calcium and other minerals are present in the bone’s outer layer, which is critical for assessing structural integrity.

Why It’s Done

Your healthcare provider may recommend this test if you have symptoms like bone pain, fractures, or if you’re at higher risk for osteoporosis due to factors like age, genetics, or certain medications.

Sample Collection and Preparation

A small piece of bone is taken from a site under local anesthesia, often from the hip or spine. The sample is then processed and analyzed in a lab to measure mineral content.

What to Expect Before the Test

No special preparation is needed, but you may be asked to stop certain medications or avoid eating/drinking for a short time before the procedure. Follow your provider’s instructions carefully.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Bone Density (Cortical)

Frequently asked questions

Bone mineral density is crucial for diagnosing conditions like osteoporosis, where bones become weak and brittle. Low density can increase fracture risk and guide treatment decisions, such as medication or lifestyle changes.
This test helps determine if your bone density is within normal limits, below normal (indicating risk), or if further evaluation is needed. Results can also monitor treatment effectiveness over time.
How long does it take to get results?
Results are typically available within 1–2 weeks after the biopsy and lab analysis. Your healthcare provider will discuss the findings with you during a follow-up visit.
Is the biopsy procedure painful?
The procedure is usually done under local anesthesia to minimize discomfort. You may feel some pressure or mild soreness afterward, but systemic pain is rare. Recovery time is short, and most people return to normal activities quickly.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy