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White Blood Cell Differential (with Tumor Marker Screening)

Published: August 9, 2026Updated: August 16, 2026

This test evaluates your white blood cell counts and checks for certain proteins that may be linked to tumor activity.

Quick summary

["It helps doctors assess immune health and monitor possible cancer-related changes in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
43446-4
Short code
Deprecated CT for Tumor WB
Synonyms
Deprecated CT for Tumor WB
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ct
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test includes a standard white blood cell differential (counting and identifying different types of white blood cells) and a screening for tumor-associated proteins. The tumor marker screening may detect substances produced by certain cancers, though not all tumors release these markers.

Why Might You Need This Test?

Doctors may order this test to monitor immune function, evaluate symptoms like fatigue or infections, or check for signs of cancer or other conditions affecting blood cells. The tumor marker screening is often part of cancer surveillance or follow-up.

What to Expect Before the Test

No special preparation is needed for the blood draw. You may have a small needle inserted into your arm, and you’ll feel a brief pinch. If you’re on blood thinners, let your doctor know before the test.

What Are Common Results and Next Steps?

Results will show your white blood cell types and any detected tumor markers. Abnormal counts or markers may prompt further testing, such as biopsies or additional imaging, to investigate potential causes.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

What does a ‘deprecated’ label mean for this test?
The term ‘deprecated’ suggests this test or method may no longer be the standard approach, possibly due to newer, more accurate techniques or clinical guidelines. Your doctor will use the most appropriate and current tests for your situation.
How often should I get this test if I have a history of cancer?
Your doctor will determine the frequency based on your cancer type, stage, and treatment plan. Regular follow-ups may include blood tests, imaging, or other screenings tailored to your needs.
Can I fast before this test?
No fasting is required for this test, as it involves a simple blood draw. However, always follow your doctor’s instructions for any specific preparations.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy