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D-dimer, plasma mass concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of D-dimer, a protein fragment produced when blood clots break down. It helps assess whether you may have a blood clot or bleeding disorder.

Quick summary

["D-dimer helps diagnose potential blood clots or bleeding risks."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
15129-0
Short code
Deprecated D Dimer PPP EIA-mCnc
Synonyms
Deprecated D Dimer PPP EIA-mCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
eia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is D-dimer Used For?

D-dimer is primarily used to evaluate conditions involving blood clotting or clot breakdown. It can help rule out deep vein thrombosis (DVT) or pulmonary embolism (clots in the lungs) when combined with other tests. It may also assist in diagnosing conditions like disseminated intravascular coagulation (DIC), where the body forms clots throughout the bloodstream.

How Is This Test Performed?

A blood sample is taken from a vein, usually in your arm. The blood is then processed to measure D-dimer levels using a specialized immunoassay method. The test is typically done on plasma, the liquid part of blood without clotting factors.

Why Might You Need This Test?

Your healthcare provider may order a D-dimer test if you have symptoms of blood clots, such as swelling, pain, or redness in the legs, shortness of breath, or chest pain. It may also be used to check for bleeding disorders or to monitor certain medical conditions affecting blood clotting.

What Are Possible Results?

Results are not provided with specific numeric ranges as they can vary based on the test method and laboratory. High levels of D-dimer may suggest recent clot formation, while very low levels may indicate no active clotting activity.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

D-dimer

Frequently asked questions

What does a high D-dimer level mean?
A high D-dimer level often suggests recent clot formation, which could be due to conditions like deep vein thrombosis, pulmonary embolism, or other clotting disorders. It does not confirm a diagnosis alone but may prompt further evaluation.
Can D-dimer levels change over time?
Yes, D-dimer levels can fluctuate depending on the presence or activity of blood clots. They may decrease as clots dissolve or remain elevated if clotting continues. Your healthcare provider will consider these changes in context with your symptoms and other test results.
Is there anything I should do before the test?
No special preparations are usually needed for a D-dimer test. However, inform your healthcare provider about any medications you are taking, especially blood thinners, as they may affect results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy