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Alpha-1 Antitrypsin (Serum) Activity

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs and other organs from damage caused by enzymes released during inflammation.

Quick summary

["Alpha-1 Antitrypsin helps prevent lung and liver damage; low levels may indicate genetic deficiency or chronic lung disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
81740-3
Short code
Deprecated ENA SS-A 52kD Ab CSF Ql IB
Synonyms
Deprecated ENA SS-A 52kD Ab CSF Ql IB
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ib
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms of lung diseases like chronic obstructive pulmonary disease (COPD) or emphysema, or if you have a family history of Alpha-1 Antitrypsin deficiency. It can also be used to monitor liver health or diagnose conditions like cirrhosis.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into a vein in your arm to draw a blood sample. This process usually takes a few minutes and is generally comfortable.

What the Test Results Mean

Results help determine if your Alpha-1 Antitrypsin levels are within normal ranges or if they are low, which could indicate a genetic disorder or other health concerns. Low levels may require further evaluation and possible treatment options.

Common Conditions Monitored

This test is particularly important for individuals with a family history of Alpha-1 Antitrypsin deficiency, as it can lead to lung diseases like emphysema or liver diseases like cirrhosis. Regular monitoring can help manage symptoms and prevent complications.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Alpha-1 Antitrypsin Deficiency

Short name

Alpha-1 Antitrypsin Activity

Frequently asked questions

How often will I need this test?
The frequency depends on your health condition and medical history. If you have a known deficiency, your doctor may recommend regular testing to monitor your levels and adjust treatment as needed. If this is a one-time screening, it may not be repeated unless symptoms or test results suggest further evaluation.
What does a low Alpha-1 Antitrypsin level mean?
A low level may indicate Alpha-1 Antitrypsin deficiency, which can cause lung diseases or liver problems. Your doctor will discuss next steps, which could include genetic counseling, lifestyle changes, or medications to manage symptoms.
Can I eat or drink anything before this test?
You can eat and drink normally before this test unless instructed otherwise by your healthcare provider. No fasting is required for this blood test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy