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Total Protein (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and globulin proteins essential for maintaining fluid balance, immune function, and tissue repair.

Quick summary

["Your blood protein levels help assess hydration, nutrition, and potential liver or kidney issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
31675-2
Short code
Deprecated GQ1b Tetra Ab Ser Ql
Synonyms
Deprecated GQ1b Tetra Ab Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It Matters in Your Health

Blood proteins play a critical role in keeping your body functioning properly. Low levels may signal dehydration, malnutrition, or problems with organs like the liver or kidneys. High levels could indicate conditions like multiple myeloma or severe dehydration.

What to Expect Before the Test

No special preparation is needed for this test. You may have a small needle inserted into your arm to draw blood. If you’re on blood thinners or have a history of bleeding issues, let your provider know before the test.

Common Causes of Abnormal Results

Low protein levels might be due to poor diet, liver disease, kidney disease, or excessive fluid loss. High protein levels could result from conditions like dehydration, multiple myeloma, or certain infections.

How This Test Is Performed

A healthcare provider will collect a blood sample from a vein in your arm using a needle. The blood is then sent to a lab for analysis. The test typically takes a few minutes, and results are usually available within 24 hours.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What does a low total protein level mean?
A low total protein level may indicate conditions such as malnutrition, liver disease, or kidney problems. It can also signal excessive fluid loss, like from vomiting or diarrhea. Your provider may recommend further tests to determine the exact cause.
What does a high total protein level mean?
High protein levels can sometimes be a sign of dehydration, severe infections, or certain blood disorders like multiple myeloma. In some cases, it may also be related to conditions that cause the body to produce too many proteins.
How often should I get this test?
The frequency of this test depends on your health status. Your healthcare provider may order it periodically if you have conditions like liver disease, kidney disease, or if you’re undergoing treatment for malnutrition or other related issues. Regular check-ups can help monitor your protein levels effectively.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy