Skip to content

Total Protein (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and globulin proteins essential for maintaining fluid balance, immune function, and tissue repair.

Quick summary

["Your blood protein levels help assess hydration, liver function, and overall protein status."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
77484-4
Short code
Deprecated Hind+Mid ft-Bl XR AP+Lat
Synonyms
Deprecated Hind+Mid ft-Bl XR AP+Lat
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Proteins Are Measured?

Total protein includes two main types: albumin and globulin. Albumin helps keep fluids in your bloodstream, while globulins support immune function and transport certain substances. Your test result reflects the combined effect of these proteins.

Why Is This Test Done?

Doctors order this test to check for conditions like dehydration, liver disease, kidney problems, or malnutrition. It can also help monitor chronic conditions like heart failure or kidney disease.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The blood is then sent to a lab where it is separated into serum (the liquid part after clotting) and analyzed for protein content using standard laboratory techniques.

What Do Results Mean?

Results are typically reported in grams per deciliter (g/dL). Low levels may indicate dehydration, liver or kidney disease, or poor nutrition, while high levels could suggest conditions like multiple myeloma or severe dehydration.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Changes in total protein levels can signal underlying health issues, such as impaired liver or kidney function, which may require further medical evaluation to determine the cause and appropriate treatment.

Short name

Total Protein

Frequently asked questions

Why might my doctor want to check my total protein level again soon?
If your initial results are outside the expected range, your doctor may repeat the test to confirm findings or investigate potential causes, such as changes in diet, medication, or underlying health conditions.
What should I do if I feel unwell before my test?
If you experience symptoms like severe vomiting, diarrhea, or signs of infection, inform your healthcare provider before the test. These conditions can affect protein levels and may require adjustments to your test plan.
Can diet or medications affect my total protein test results?
Yes, certain foods (like high-protein diets) or medications (such as steroids) can influence protein levels. Always discuss your diet, medications, and recent health changes with your doctor before your test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy