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Total Protein (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and other proteins like globulins.

Quick summary

["Your blood protein levels help assess overall health and detect conditions like malnutrition or kidney disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
77477-8
Short code
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Synonyms
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Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It’s Done

Doctors may order a total protein test to check for signs of kidney disease, liver problems, malnutrition, or certain immune system disorders. It can also help monitor conditions like multiple myeloma or chronic infections.

What to Expect

Blood is collected in a tube and sent to the lab, where it’s analyzed to determine protein concentration.

Normal vs. Abnormal Results

While reference ranges vary by lab, lower than expected protein levels might suggest malnutrition or severe illness, while higher levels could indicate conditions like multiple myeloma or dehydration from kidney problems.

Common Conditions Affecting Results

Conditions like kidney disease, liver disease, or chronic infections can alter protein levels. Some medications or dietary factors may also influence results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Protein

Frequently asked questions

How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times.
What if my results are outside the normal range?
Your doctor will discuss your results in detail, considering your medical history and symptoms. Abnormal levels may prompt further testing or additional questions about your health.
Can I eat or drink before this test?
For most protein tests, fasting isn’t required, but follow your doctor’s instructions if they specify any dietary restrictions for your test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy