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Serum or plasma concentration of total protein by nephelometry (bromocresol purple method)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood, which helps your body function properly. Proteins are essential for healing, transporting nutrients, and maintaining fluid balance.

Quick summary

["Your blood protein levels can indicate overall health and help diagnose conditions like dehydration, liver disease, or kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
77480-2
Short code
Deprecated Hind+Mid ft-R XR
Synonyms
Deprecated Hind+Mid ft-R XR
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors may order this test to check for signs of illness, monitor chronic conditions, or evaluate symptoms like swelling, fatigue, or changes in urine output. It can also help assess how well your kidneys or liver are working.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if it’s part of a larger blood panel. Wear comfortable clothing and bring any medications you’re currently taking.

What Happens During the Test?

A healthcare provider will draw blood from a vein in your arm. You may feel a slight pinch, but it usually doesn’t cause discomfort. The blood is then sent to a lab for analysis.

What Are Possible Results?

Results are expressed in grams per deciliter (g/dL). Low levels may suggest malnutrition, kidney disease, or severe dehydration, while very high levels could indicate conditions like multiple myeloma or severe liver disease.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal protein levels can signal underlying health issues. Low protein may indicate poor nutrient absorption, organ dysfunction, or excessive fluid loss. High protein levels could point to conditions like inflammation, infections, or certain cancers. Always discuss results with your doctor for personalized interpretation.

Short name

Total protein

Frequently asked questions

What causes low total protein levels?
Low protein levels can result from conditions like kidney disease, liver failure, severe infections, malnutrition, or excessive vomiting/diarrhea. Your doctor may also check for conditions like celiac disease or protein-losing syndromes.
What causes high total protein levels?
High protein levels may be due to chronic infections, inflammation, multiple myeloma, or dehydration. Rarely, it could be linked to certain medications or genetic disorders.
How often should I get this test?
Frequency depends on your health status. Doctors may recommend this test annually for chronic conditions like kidney disease or liver issues, or more often if you have symptoms like unexplained weight loss, swelling, or fatigue.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy