Homocysteine in Serum (Mass Concentration)
This test measures the amount of homocysteine, a type of amino acid, in your blood. Homocysteine is involved in metabolism but can build up when certain nutrients are low or when genetic factors are present.
["Homocysteine levels may indicate risks for heart disease or other health issues."]
Key facts at a glance
- LOINC
- 22673-8
- Short code
- Deprecated Homocystine SerPl-sCnc
- Synonyms
- Deprecated Homocystine SerPl-sCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have a history of heart disease, stroke, or blood vessel problems. It could also be checked if you have symptoms like fatigue, numbness, or memory issues that might be linked to nutrient deficiencies or genetic conditions.
What to Expect Before the Test
No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if it’s part of a broader metabolic evaluation. Bring any medications you’re taking, as some may affect results.
What the Test Involves
A blood sample will be drawn from a vein in your arm. This is a quick, painless procedure that usually takes a few minutes. You may feel a slight pinch, but most people tolerate it well.
What the Results Mean
Results are compared to general reference ranges, but individual needs vary. High levels may signal risks for vascular issues, while low levels could indicate deficiencies in vitamins like folate or B12.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated homocysteine levels are linked to increased risks of cardiovascular disease, including heart attacks and strokes. It may also be associated with nerve damage (neuropathy) or osteoporosis. Low levels are less commonly significant but could suggest underlying deficiencies that need addressing.
Short name
Homocysteine Level
Frequently asked questions
How long does it take to get results?
What causes homocysteine levels to be high?
Can I lower my homocysteine levels naturally?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy