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Lumbar Sacral Acetylcholine Receptor Antibody Screening (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies that may be linked to certain autoimmune conditions affecting the nervous system, including Lambert-Eaton myasthenic syndrome.

Quick summary

["This screening helps identify potential nerve signal problems caused by immune system activity."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
38060-0
Short code
Deprecated Lumbrosac+C+T-spine MRI Sagit
Synonyms
Deprecated Lumbrosac+C+T-spine MRI Sagit
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
mri
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like muscle weakness, fatigue, or difficulty with coordination, especially if they suggest a nerve-related autoimmune disorder. It can also be part of a broader evaluation for conditions like Lambert-Eaton myasthenic syndrome.

What to Expect Before the Test

You’ll typically provide a blood sample from a vein in your arm. No special preparation is needed, but inform your doctor about any medications you’re taking.

What the Test Results Mean

Positive results suggest the presence of acetylcholine receptor antibodies, which may indicate an autoimmune condition. However, further testing and clinical correlation are required to confirm a diagnosis.

Common Symptoms Linked to This Test

Symptoms like muscle weakness, especially in the arms or legs, fatigue, difficulty swallowing, or blurred vision may prompt this screening. These symptoms can vary widely and may not directly relate to test results alone.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Acetylcholine Receptor Antibody Screen

Frequently asked questions

What does a positive result mean?
A positive result indicates the presence of acetylcholine receptor antibodies, which are associated with Lambert-Eaton myasthenic syndrome and other autoimmune nerve disorders. However, results alone do not diagnose the condition. Your doctor will review your symptoms, medical history, and possibly additional tests to determine the next steps.
How often should I get this test?
The frequency depends on your symptoms, medical history, and ongoing treatment. Your healthcare provider will guide you on whether repeat testing is needed, especially if symptoms persist or worsen.
Can lifestyle changes help with symptoms related to this test?
While this test itself doesn’t treat symptoms, managing underlying conditions may involve lifestyle adjustments like a balanced diet, regular exercise (if tolerated), and avoiding triggers like stress or certain medications. Always follow your doctor’s advice for personalized care.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy