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MALT1 Gene Rearrangement, Qualitative — Deprecated

Published: August 9, 2026Updated: August 17, 2026

A qualitative molecular test that looks for a rearrangement involving the MALT1 gene, an alteration that can occur in some B-cell lymphomas.

Quick summary

["Detecting a MALT1 rearrangement may support a diagnosis of MALT lymphoma when combined with clinical and pathology findings."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
21379-3
Short code
Deprecated Malt IgG RAST Ql
Synonyms
Deprecated Malt IgG RAST Ql
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
7
Ref high
56
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84484
SNOMED
302773008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This test examines genetic material for a rearrangement involving the MALT1 gene. Such changes can be found in some B-cell lymphomas, including extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue type.

Why might I need this test?

It may be used when symptoms, imaging, or tissue findings suggest a lymphoma and the diagnosis remains uncertain. Results are interpreted together with other pathology tests and clinical information.

How is the test performed?

DNA is obtained from an appropriate blood or tissue sample and analyzed using a molecular method to determine whether a qualifying MALT1 rearrangement is present. The result is reported as detected or not detected.

How do I prepare for the test?

Preparation depends on the specimen and the laboratory's instructions. A tissue biopsy may require local anesthesia, while a blood sample generally requires no special preparation; confirm any fasting or medication instructions with your care team.

Reference range

Adult males: 7-56 U/L; Adult females: 7-43 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

MALT1 rearrangement test

Frequently asked questions

Does a positive result mean I have cancer?
No. A positive result shows that the tested sample contains a MALT1 gene rearrangement, but it must be interpreted with symptoms, imaging, and other pathology findings to determine its clinical significance.
Does a negative result rule out lymphoma?
No. Some lymphomas do not contain a MALT1 rearrangement, so a negative result alone cannot rule out cancer.
Why is this test listed as deprecated?
Newer molecular testing methods may be preferred for evaluating suspected lymphoma and may detect a broader range of relevant genetic changes. The laboratory can confirm whether another test is recommended.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy