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Total Protein (Serum or Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins.

Quick summary

["Your blood protein levels help assess overall health and detect potential issues like malnutrition or kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
23317-1
Short code
Deprecated NSDV Ab Titr Ser
Synonyms
Deprecated NSDV Ab Titr Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors may order a total protein test to check for conditions like malnutrition, kidney disease, liver problems, or certain types of infections. It can also help diagnose autoimmune disorders or monitor long-term health in people with chronic illnesses.

What Does the Result Mean?

Higher-than-normal levels might suggest conditions like multiple myeloma, severe dehydration, or certain inflammatory diseases. Lower-than-normal levels could indicate malnutrition, kidney disease, or liver problems. However, results alone don’t diagnose a condition—your doctor will consider your full medical picture.

Sample Preparation and Collection

This test is typically done on a blood sample collected from a vein in your arm. You may be asked to fast before the test, but this isn’t always required. Avoid strenuous activity or certain medications for a few days before your appointment if instructed.

What to Expect During the Test

The process is quick and usually painless. A healthcare professional will insert a small needle into your vein to draw blood. You may feel a slight pinch, but the procedure takes only a few minutes. You can usually return to normal activities immediately afterward.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What causes low total protein levels?
Low total protein levels can result from conditions like malnutrition, kidney disease, liver problems, or certain infections. Chronic diseases, such as inflammatory bowel disease or autoimmune disorders, may also lead to reduced protein synthesis or increased protein loss.
What causes high total protein levels?
High total protein levels can occur due to dehydration, multiple myeloma (a type of blood cancer), severe infections, or certain inflammatory conditions. Rarely, high protein levels may be linked to conditions like paraneoplastic syndromes (protein changes due to cancer) or certain genetic disorders.
How often should I get this test?
The frequency of this test depends on your health condition. If you have a chronic illness like kidney disease or liver disease, your doctor may recommend regular monitoring. Otherwise, this test is often done as needed for diagnostic or screening purposes, such as during pregnancy, before surgery, or if symptoms suggest an underlying issue.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy