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Total Protein in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins. Proteins help maintain fluid balance, support immunity, and transport nutrients.

Quick summary

["Your blood protein levels can signal health issues or help guide treatment decisions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
9785-7
Short code
Deprecated O and P Prep Stl
Synonyms
Deprecated O and P Prep Stl
Category
chemistry
Sample
stool
Container
Clean container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ova-and-parasite-preparation
Specimen volume
5 g
Stability
Refrigerated: 24h, Frozen: 7d
TAT
4–24 hours
Order
routine

Why This Test Matters

Blood proteins are vital for many bodily functions, including keeping fluids in the right places, fighting infections, and helping blood clot properly. Low or high protein levels can indicate conditions like kidney disease, liver problems, malnutrition, or certain cancers.

What to Expect Before the Test

No special preparation is needed for this test. You may have a small needle inserted into your arm or vein to draw blood. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

Your results will show your total protein concentration in grams per deciliter (g/dL). While reference ranges vary by lab, values outside typical ranges may prompt further testing to explore underlying causes.

Common Conditions Affecting Results

Low protein levels (hypoproteinemia) can occur due to kidney disease, liver failure, severe infections, or poor nutrition. High protein levels (hyperproteinemia) may signal dehydration, multiple myeloma, or other blood disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

How often do I need this test?
Your doctor may order this test periodically if you have conditions like kidney disease, liver disease, or if you’re receiving treatments that affect protein levels. Routine screening isn’t typically recommended unless you’re at higher risk.
What if my results are abnormal?
If your protein levels are outside the expected range, your healthcare provider will discuss next steps, which may include additional tests (like albumin or globulin tests) or further evaluation of your health condition.
Does diet affect this test?
Dietary changes alone won’t alter protein test results, but certain foods (like high-protein diets) or medical conditions (like kidney disease) can influence protein levels. Follow your provider’s guidance for any dietary adjustments.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy