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Alpha-1 Antitrypsin (A1AT) Serum Level

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs from damage caused by enzymes released during inflammation.

Quick summary

["A1AT levels help assess lung and liver health, especially in conditions like emphysema or chronic lung diseases."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
32357-6
Short code
Deprecated O+P Stl
Synonyms
Deprecated O+P Stl
Category
chemistry
Sample
stool
Container
Clean container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ova-parasite-preparation
Specimen volume
5 g
Stability
Refrigerated: 24h, Frozen: 7d
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like chronic cough, shortness of breath, or liver issues. It’s also used to monitor conditions like alpha-1 antitrypsin deficiency, which can lead to lung disease or cirrhosis.

What to Expect Before the Test

No special preparation is needed. You may have a blood draw from a vein in your arm, similar to other blood tests. You can eat and drink normally before the test.

What the Results Mean

Lower-than-normal levels may indicate a genetic condition called alpha-1 antitrypsin deficiency, which can affect lung or liver function. Higher-than-normal levels might be seen in certain liver diseases or infections.

Common Conditions Monitored

This test helps diagnose and manage conditions like chronic obstructive pulmonary disease (COPD), emphysema, and liver diseases such as cirrhosis or hepatitis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Alpha-1 Antitrypsin Deficiency

Short name

A1AT Level

Frequently asked questions

What causes low A1AT levels?
Low levels are often linked to a genetic mutation passed down through families. This can lead to lung diseases like emphysema or liver diseases like cirrhosis, especially if symptoms develop early in life.
How often should I get this test?
If you have a known alpha-1 antitrypsin deficiency, your doctor may recommend regular testing to monitor your condition and adjust treatment as needed. Frequency depends on your specific health plan and symptoms.
Can diet or supplements affect A1AT levels?
Dietary changes or supplements typically do not significantly alter A1AT levels. However, if you have liver disease, your doctor may advise avoiding certain foods or medications that could worsen your condition.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy