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Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and other proteins like globulins.

Quick summary

["Total protein levels help assess overall protein balance and potential nutritional or liver issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
27825-9
Short code
Deprecated PA Ab Bld Ql
Synonyms
Deprecated PA Ab Bld Ql
Category
hematology
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check for conditions affecting protein production, such as liver disease, kidney problems, or malnutrition. It can also help diagnose or monitor certain cancers or infections.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the draw if your lab requires it. Bring any medications or supplements you’re taking.

How the Test Works

A blood sample is taken from a vein, usually in your arm. The blood is then separated into serum (the liquid part after clotting) for analysis.

What the Results Mean

Higher-than-expected levels may suggest dehydration, multiple myeloma, or liver disease, while lower levels could indicate malnutrition, kidney disease, or severe infections.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: Elevated total protein may indicate chronic conditions like multiple myeloma or liver dysfunction, where protein synthesis is disrupted. Low levels often reflect malnutrition, chronic liver disease, or kidney impairment, which can impair protein retention or production.

Short name

Total Protein

Frequently asked questions

What causes abnormal protein levels?
Abnormal results can stem from medical conditions like liver disease, kidney disease, infections, or certain cancers. Lifestyle factors (e.g., poor diet) or medications may also play a role.
How often should I get this test?
Your doctor will determine frequency based on your health needs—some patients get it yearly, while others may need it more often if monitoring a chronic condition.
Can I eat or drink before this test?
Check with your lab or doctor about fasting requirements, but generally, you can drink water unless instructed otherwise. Avoid alcohol or heavy meals before the draw.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy